ST6GALNAC5

Across TCGA patient cohorts, ST6GALNAC5 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ST6GALNAC5-associated genes across cancer lineages are IRS1, NF-kB-p65_pS536, and Snail. Each is linked with ST6GALNAC5 in more than 2 cancer types. Because this analysis shows association rather than direction, both ST6GALNAC5-to-partner and partner-to-ST6GALNAC5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IRS1 grouped by ST6GALNAC5-low versus ST6GALNAC5-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ST6GALNAC5→partner) and Y-score (partner→ST6GALNAC5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	IRS1 →	+0.151	+2.824	.027	.034	3	3
SKCM	NF-kB-p65_pS536 →	+0.459	+2.321	.008	.033	3	2
SKCM	Snail →	-0.156	-3.446	.042	.005	3	2
SKCM	Collagen-VI →	-0.307	-3.169	.045	.018	3	2
UCEC	eEF2 →	+0.392	+2.999	.004	.035	3	2
UCEC	JNK2 →	+0.213	+1.884	.005	.030	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

IRS1 by ST6GALNAC5 expression — SKCM

Explore this box plot interactively →