ST6GALNAC5

Across TCGA pan-cancer cohorts, ST6GALNAC5 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated ST6GALNAC5 data layer compared with 5 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in mesothelioma (MESO), where higher ST6GALNAC5 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated ST6GALNAC5 expression acts as an unfavorable survival marker, although some lineages such as SKCM and HNSC show a favorable association.

MESO, SKCM, and HNSC are the cancer types where ST6GALNAC5 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Median	All	0.418	0.660	<.001	114	view →
SKCM	OS	Quartile	All	0.422	0.243	<.001	72	view →
HNSC	DFS	Median	IV	0.678	0.474	<.001	25	view →
LUSC	DFS	Quartile	II,III,IV	0.254	0.501	.003	23	view →
ACC	DFS	Tertile	III,IV	0.451	0.082	.006	22	view →
KIRP	DFS	Tertile	All	0.951	0.853	.013	19	view →
PAAD	DFS	Quartile	All	0.541	0.208	.004	19	view →
UVM	OS	Median	III,IV	0.245	0.836	.002	15	view →
SCLC	OS	Tertile	All	0.822	0.605	.008	15	view →
BLCA	OS	Tertile	All	0.586	0.711	.032	13	view →
SARC	OS	Median	All	0.904	0.740	.002	13	view →
UCEC	DFS	Tertile	All	0.774	0.866	.010	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

ST6GALNAC5–MESO (OS)

Open the MESO breakdown →