ST6GALNAC4

Across TCGA patient cohorts, ST6GALNAC4 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ST6GALNAC4-associated genes across cancer lineages are mTOR, RAD51, and Stathmin. Each is linked with ST6GALNAC4 in more than 1 cancer types. Because this analysis shows association rather than direction, both ST6GALNAC4-to-partner and partner-to-ST6GALNAC4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR grouped by ST6GALNAC4-low versus ST6GALNAC4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ST6GALNAC4→partner) and Y-score (partner→ST6GALNAC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR →	-0.245	-2.700	<.001	.006	3	1
UCEC	RAD51 →	+0.179	+2.321	.004	.034	3	1
UCEC	Stathmin →	+0.124	+2.000	.046	.032	3	1
UCEC	VHL →	-0.958	-2.321	.001	.034	3	1
UCEC	ATM →	-0.475	-2.986	.020	.035	3	1
UCEC	ERK2 →	+0.317	+2.459	<.001	.019	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

mTOR by ST6GALNAC4 expression — UCEC

Explore this box plot interactively →