ST6GALNAC2

Across TCGA patient cohorts, ST6GALNAC2 mutation is significantly associated with the RNA expression of many other genes, with 889 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ST6GALNAC2-associated genes across cancer lineages are MIR1289-2, RNU6-543P, and MIR518E. Each is linked with ST6GALNAC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ST6GALNAC2-to-partner and partner-to-ST6GALNAC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR1289-2 grouped by ST6GALNAC2-low versus ST6GALNAC2-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ST6GALNAC2→partner) and Y-score (partner→ST6GALNAC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	MIR1289-2 →	+0.322	+6.111	<.001	.002	3	2
BRCA	RNU6-543P →	+0.283	+8.055	<.001	.007	3	2
SKCM	MIR518E →	+0.543	+5.328	<.001	.003	3	2
CESC	MIR1252 →	+0.456	+4.669	<.001	.007	3	2
BRCA	RNU6-334P →	+0.382	+7.731	<.001	.009	3	2
HNSC	RAB9BP1 →	+0.065	+5.822	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 889 associations by consensus.

MIR1289-2 by ST6GALNAC2 expression — HNSC

Explore this box plot interactively →