ST6GALNAC2

Across TCGA pan-cancer cohorts, ST6GALNAC2 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated ST6GALNAC2 data layer compared with 3 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher ST6GALNAC2 RNA is associated with better overall survival. In most high-consensus cancer types, elevated ST6GALNAC2 expression acts as an unfavorable survival marker, although some lineages such as BRCA and LUAD show a favorable association.

BRCA, LGG, and LUAD are the cancer types where ST6GALNAC2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	OS	Tertile	All	0.959	0.899	<.001	74	view →
LGG	DFS	Tertile	All	0.378	0.570	<.001	40	view →
LUAD	DFS	Tertile	III,IV	0.832	0.448	.004	39	view →
UCS	DFS	Median	IV	0.952	0.367	.001	30	view →
HNSC	OS	Tertile	III,IV	0.446	0.772	.005	23	view →
PAAD	DFS	Quartile	All	0.424	0.648	.003	18	view →
READ	DFS	Quartile	III,IV	0.438	0.953	.001	17	view →
KIRC	DFS	Tertile	All	0.769	0.541	.022	15	view →
UCEC	DFS	Tertile	All	0.890	0.786	.003	14	view →
ACC	DFS	Tertile	III,IV	0.770	0.138	.002	10	view →
STAD	OS	Median	III,IV	0.741	0.526	.016	6	view →
COAD	DFS	Median	II,III,IV	0.571	0.725	.016	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

ST6GALNAC2–BRCA (OS)

Open the BRCA breakdown →