ST6GALNAC2

Across TCGA patient cohorts, ST6GALNAC2 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ST6GALNAC2-associated genes across cancer lineages are A-Raf_pS299, STAT3_pY705, and 14-3-3_beta. Each is linked with ST6GALNAC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ST6GALNAC2-to-partner and partner-to-ST6GALNAC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by ST6GALNAC2-low versus ST6GALNAC2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ST6GALNAC2→partner) and Y-score (partner→ST6GALNAC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.186	-3.000	.007	.037	3	1
UCEC	STAT3_pY705 →	-0.466	-3.000	.002	.037	3	1
UCEC	14-3-3_beta →	-0.140	-2.986	.016	.037	2	1
UCEC	Ku80 →	+0.354	+3.013	.009	.019	2	1
UCEC	Paxillin →	+0.404	+3.000	.006	.037	1	1
UCEC	PRAS40_pT246 →	+0.244	+3.013	.014	.019	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

A-Raf_pS299 by ST6GALNAC2 expression — UCEC

Explore this box plot interactively →