ST6GALNAC1

Across TCGA patient cohorts, ST6GALNAC1 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ST6GALNAC1-associated genes across cancer lineages are G6PD, N-Cadherin, and PREX1. Each is linked with ST6GALNAC1 in more than 2 cancer types. Because this analysis shows association rather than direction, both ST6GALNAC1-to-partner and partner-to-ST6GALNAC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, G6PD grouped by ST6GALNAC1-low versus ST6GALNAC1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ST6GALNAC1→partner) and Y-score (partner→ST6GALNAC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	G6PD →	-0.313	-2.979	.037	.036	3	3
UCEC	N-Cadherin →	+0.336	+3.179	<.001	.010	3	2
UCEC	PREX1 →	-0.314	-2.999	.014	.035	3	2
UCEC	STAT3_pY705 →	-0.605	-3.700	<.001	.001	3	2
UCEC	Caspase-8 →	-0.283	-3.432	.015	.005	3	2
UCEC	14-3-3_beta →	-0.094	-2.973	.045	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

G6PD by ST6GALNAC1 expression — UCEC

Explore this box plot interactively →