ST6GALNAC1

Across TCGA pan-cancer cohorts, ST6GALNAC1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of ST6GALNAC1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where ST6GALNAC1 RNA is repressed in tumor relative to normal tissue. In most cancer types ST6GALNAC1 is over-expressed in tumor, although a few such as HNSC and COAD show the opposite, repressed pattern.

HNSC, COAD, and KICH are the cancer types where ST6GALNAC1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ST6GALNAC1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	IV	−1.997	<.001	11	view →
COAD	Female	All	−1.673	<.001	10	view →
KICH	All	All	−0.456	<.001	7	view →
BRCA	All	III,IV	−1.088	<.001	6	view →
LUAD	Female	II,III,IV	+1.988	<.001	5	view →
KIRC	All	IV	−0.260	.003	5	view →
THCA	Male	III,IV	−0.422	.007	3	view →
PAAD	All	All	+2.362	.015	2	view →
UCEC	All	All	+1.002	.035	2	view →
PRAD	All	All	+0.837	.001	2	view →
KIRP	Male	All	−0.212	.001	2	view →
LUSC	Male	II,III,IV	−0.878	.032	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

ST6GALNAC1–HNSC

Open the HNSC breakdown →