ST6GAL2-IT1

Across TCGA pan-cancer cohorts, ST6GAL2-IT1 RNA is linked to patient survival in 15 of 34 cancer types, making it the most broadly survival-associated ST6GAL2-IT1 data layer.

The strongest signal is observed in kidney chromophobe (KICH), where higher ST6GAL2-IT1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated ST6GAL2-IT1 expression acts as an unfavorable survival marker, although some lineages such as LGG and BRCA show a favorable association.

KICH, LGG, and BRCA are the cancer types where ST6GAL2-IT1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	OS	Tertile	All	0.683	0.941	.004	51	view →
LGG	OS	Median	All	0.551	0.349	<.001	36	view →
BRCA	OS	Tertile	IV	0.942	0.362	.004	24	view →
UCEC	DFS	Median	All	0.524	0.718	.007	24	view →
COAD	DFS	Tertile	III,IV	0.498	0.688	.028	18	view →
LAML	DFS	Tertile	All	0.772	0.531	.018	18	view →
LUAD	DFS	Tertile	IV	0.203	0.631	.024	18	view →
READ	DFS	Tertile	IV	0.241	0.706	.002	14	view →
SARC	OS	Tertile	All	0.746	0.917	.005	13	view →
SKCM	DFS	Tertile	III,IV	0.557	0.234	.030	12	view →
KIRC	DFS	Median	All	0.858	0.773	.010	12	view →
STAD	DFS	Tertile	IV	0.148	0.441	.041	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 15 lineages.

ST6GAL2-IT1–KICH (OS)

Open the KICH breakdown →