ST6GAL2-IT1

Across TCGA pan-cancer cohorts, ST6GAL2-IT1 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of ST6GAL2-IT1’s most consistent transcriptional readouts.

The strongest signal is observed in breast invasive carcinoma (BRCA), where ST6GAL2-IT1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ST6GAL2-IT1 is over-expressed in tumor, although a few such as KICH and READ show the opposite, repressed pattern.

BRCA, KICH, and READ are the cancer types where ST6GAL2-IT1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ST6GAL2-IT1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BRCA	All	III,IV	+0.454	<.001	6	view →
KICH	All	II,III,IV	−0.069	.021	4	view →
READ	All	All	−0.358	.014	2	view →
ESCA	Female	All	−0.350	.012	2	view →
LIHC	Male	All	−0.167	<.001	2	view →
THCA	Male	III,IV	−0.938	.017	1	view →
COAD	Female	III,IV	−0.198	.019	1	view →
KIRC	Male	All	+0.078	.042	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

ST6GAL2-IT1–BRCA

Open the BRCA breakdown →