ST3GAL5

Across TCGA patient cohorts, ST3GAL5 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ST3GAL5-associated genes across cancer lineages are P-Cadherin, eEF2, and eIF4E. Each is linked with ST3GAL5 in more than 1 cancer types. Because this analysis shows association rather than direction, both ST3GAL5-to-partner and partner-to-ST3GAL5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, P-Cadherin grouped by ST3GAL5-low versus ST3GAL5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ST3GAL5→partner) and Y-score (partner→ST3GAL5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	P-Cadherin →	-0.138	-2.690	.012	.006	3	2
UCEC	eEF2 →	+0.330	+2.000	.016	.030	3	1
UCEC	eIF4E →	+0.165	+1.678	.041	.023	3	1
UCEC	eIF4G →	+0.248	+1.678	.037	.023	3	1
UCEC	A-Raf_pS299 →	-0.138	-2.459	.002	.018	3	1
UCEC	GAPDH →	+0.581	+3.321	.004	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

P-Cadherin by ST3GAL5 expression — UCEC

Explore this box plot interactively →