ST3GAL5-AS1

Across TCGA pan-cancer cohorts, ST3GAL5-AS1 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of ST3GAL5-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where ST3GAL5-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types ST3GAL5-AS1 is over-expressed in tumor, although a few such as COAD and LUSC show the opposite, repressed pattern.

COAD, LUSC, and UCEC are the cancer types where ST3GAL5-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ST3GAL5-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	II,III,IV	−0.167	<.001	9	view →
LUSC	Female	II,III,IV	−1.112	<.001	6	view →
UCEC	All	All	−0.870	<.001	6	view →
BRCA	All	III,IV	−0.419	<.001	6	view →
READ	All	II,III,IV	−0.302	<.001	4	view →
KIRC	All	All	−0.180	.003	4	view →
LUAD	All	II,III,IV	−0.484	.002	3	view →
PRAD	All	All	−0.400	<.001	2	view →
LIHC	All	All	+0.111	.019	2	view →
KICH	All	All	−0.322	.029	1	view →
HNSC	All	III,IV	+0.184	.028	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

ST3GAL5-AS1–COAD

Open the COAD breakdown →