ST3GAL4

Across TCGA pan-cancer cohorts, ST3GAL4 mass-spec protein differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of ST3GAL4’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where ST3GAL4 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types ST3GAL4 is over-expressed in tumor, although a few such as HNSC and COAD show the opposite, repressed pattern.

HNSC, COAD, and PDAC are the cancer types where ST3GAL4 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ST3GAL4 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	IV	−0.610	<.001	11	view →
COAD	All	All	−0.285	.001	6	view →
PDAC	Female	All	+1.128	<.001	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

ST3GAL4–HNSC

Open the HNSC breakdown →