ST3GAL4

Across TCGA pan-cancer cohorts, ST3GAL4 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated ST3GAL4 data layer compared with 1 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher ST3GAL4 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated ST3GAL4 expression acts as an unfavorable survival marker, although some lineages such as COAD and ESCA show a favorable association.

UVM, ACC, and LUAD are the cancer types where ST3GAL4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	All	0.416	0.764	<.001	121	view →
ACC	DFS	Median	All	0.166	0.772	<.001	117	view →
LUAD	OS	Median	All	0.606	0.759	<.001	89	view →
KIRP	OS	Tertile	All	0.864	0.989	<.001	59	view →
LIHC	OS	Median	III,IV	0.334	0.714	<.001	57	view →
COAD	DFS	Median	III,IV	0.657	0.467	.001	45	view →
LUSC	DFS	Median	II,III,IV	0.231	0.485	<.001	45	view →
LGG	DFS	Median	All	0.656	0.816	<.001	39	view →
ESCA	OS	Median	II,III,IV	0.622	0.382	.006	32	view →
STAD	DFS	Tertile	II,III,IV	0.213	0.450	.020	29	view →
BRCA	OS	Quartile	II,III,IV	0.862	0.939	.002	29	view →
HNSC	OS	Tertile	All	0.562	0.786	.003	27	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

ST3GAL4–UVM (OS)

Open the UVM breakdown →