ST3GAL3-AS1

Across TCGA pan-cancer cohorts, ST3GAL3-AS1 RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of ST3GAL3-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where ST3GAL3-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types ST3GAL3-AS1 is over-expressed in tumor, although a few such as HNSC and BRCA show the opposite, repressed pattern.

HNSC, BRCA, and KIRC are the cancer types where ST3GAL3-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ST3GAL3-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	All	−0.644	.010	6	view →
BRCA	All	All	−0.325	<.001	6	view →
KIRC	All	All	+0.070	.001	6	view →
LUSC	All	All	+0.464	.001	3	view →
COAD	Female	All	−0.076	.005	2	view →
KIRP	Female	All	+0.163	.039	1	view →
KICH	All	All	−0.087	.024	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

ST3GAL3-AS1–HNSC

Open the HNSC breakdown →