ST20-AS1

Across TCGA pan-cancer cohorts, ST20-AS1 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of ST20-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where ST20-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types ST20-AS1 is over-expressed in tumor, although a few such as LUAD and THCA show the opposite, repressed pattern.

LUAD, THCA, and LUSC are the cancer types where ST20-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ST20-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Male	II,III,IV	−1.057	<.001	9	view →
THCA	Male	II,III,IV	−0.526	<.001	9	view →
LUSC	All	II,III,IV	−0.650	<.001	6	view →
CHOL	All	All	+0.485	<.001	5	view →
COAD	Male	II,III,IV	−0.271	.001	5	view →
LIHC	All	All	+0.312	<.001	3	view →
READ	Female	All	−0.364	.032	2	view →
PRAD	All	All	+0.288	.028	2	view →
BLCA	Male	IV	−0.725	.024	1	view →
HNSC	All	III,IV	+0.270	.049	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

ST20-AS1–LUAD

Open the LUAD breakdown →