ST18

Across TCGA pan-cancer cohorts, ST18 Mutation is linked to patient survival in 12 of 34 cancer types, making it a survival-associated ST18 data layer compared with 22 for mass-spec protein.

The strongest signal is observed in thyroid carcinoma (THCA), where higher ST18 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated ST18 expression acts as an unfavorable survival marker, although some lineages such as UCEC and SKCM show a favorable association.

THCA, ACC, and STAD are the cancer types where ST18 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THCA	DFS	Median	All	0.049	0.828	<.001	24	view →
ACC	DFS	Median	All	0.244	0.783	<.001	19	view →
STAD	OS	Median	IV	0.001	0.544	<.001	12	view →
READ	OS	Median	III,IV	0.644	0.932	<.001	10	view →
LUAD	DFS	Median	All	0.449	0.780	.002	8	view →
UCEC	DFS	Median	All	0.814	0.626	.012	8	view →
LUSC	OS	Median	All	0.176	0.724	.018	6	view →
GBM	DFS	Median	All	0.095	0.259	.033	6	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
LGG	DFS	Median	All	0.185	0.826	<.001	6	view →
KIRP	OS	Median	All	0.192	0.705	.015	4	view →
SKCM	OS	Median	II,III,IV	0.927	0.815	.017	4	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 12 lineages.

ST18–THCA (DFS)

Open the THCA breakdown →