ST14

Across TCGA pan-cancer cohorts, ST14 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated ST14 data layer compared with 24 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher ST14 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated ST14 expression acts as an unfavorable survival marker, although some lineages such as UCEC and PDAC show a favorable association.

CCRCC, UCEC, and PDAC are the cancer types where ST14 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	III,IV	0.145	0.774	.016	18	view →
UCEC	OS	Quartile	All	1.000	0.858	.010	12	view →
PDAC	DFS	Tertile	III,IV	0.683	0.159	.010	11	view →
LUAD	OS	Median	All	0.664	0.947	.012	9	view →
GBM	OS	Median	All	0.415	0.662	.004	8	view →
LSCC	DFS	Median	All	0.982	0.888	.026	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

ST14–CCRCC (DFS)

Open the CCRCC breakdown →