SSX4B

Across TCGA pan-cancer cohorts, SSX4B RNA is linked to patient survival in 12 of 34 cancer types, making it the most broadly survival-associated SSX4B data layer compared with 1 for mutation status.

The strongest signal is observed in thymoma (THYM), where higher SSX4B RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SSX4B expression acts as an unfavorable survival marker, although some lineages such as STAD and SKCM show a favorable association.

THYM, KICH, and HNSC are the cancer types where SSX4B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THYM	DFS	Tertile	All	0.119	0.765	<.001	132	view →
KICH	DFS	Tertile	All	0.081	0.904	<.001	90	view →
HNSC	OS	Tertile	III,IV	0.514	0.735	.001	90	view →
UVM	DFS	Quartile	II,III,IV	0.448	0.857	<.001	70	view →
KIRP	DFS	Tertile	All	0.519	0.912	<.001	63	view →
STAD	OS	Tertile	IV	0.805	0.283	.031	18	view →
COAD	OS	Tertile	All	0.252	0.682	.025	18	view →
LUAD	DFS	Tertile	IV	0.188	0.736	.001	18	view →
KIRC	OS	Tertile	II,III,IV	0.442	0.723	.038	12	view →
READ	DFS	Tertile	IV	0.255	0.628	.020	9	view →
THCA	DFS	Quartile	IV	0.436	0.762	.016	6	view →
SKCM	OS	Tertile	All	0.712	0.332	.021	3	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 12 lineages.

SSX4B–THYM (DFS)

Open the THYM breakdown →