SSX3

Across TCGA patient cohorts, SSX3 mutation is significantly associated with the RNA expression of many other genes, with 1,183 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SSX3-associated genes across cancer lineages are TAF9, THOP1, and NUP188. Each is linked with SSX3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SSX3-to-partner and partner-to-SSX3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TAF9 grouped by SSX3-low versus SSX3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SSX3→partner) and Y-score (partner→SSX3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TAF9 →	+0.604	+2.584	<.001	<.001	3	2
UCEC	THOP1 →	+0.428	+1.773	.002	.008	3	2
UCEC	NUP188 →	+0.586	+2.201	<.001	<.001	3	2
UCEC	JOSD1 →	+0.369	+2.439	.006	.001	3	2
UCEC	LRRC59 →	+0.440	+1.885	.002	.001	3	2
UCEC	DAP →	+0.442	+1.906	.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,183 associations by consensus.

TAF9 by SSX3 expression — UCEC

Explore this box plot interactively →