Across TCGA pan-cancer cohorts, SSX3 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of SSX3’s most consistent transcriptional readouts.
The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where SSX3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SSX3 is over-expressed in tumor.
LIHC and THCA are the cancer types where SSX3 tumor–normal differential expression is most reproducible.