SSU72

Across TCGA cell cohorts, SSU72 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,165 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SSU72-associated GO terms across cancer lineages are RISC complex assembly, Regulation of DNA stability, and Cellular response to methionine. Each is linked with SSU72 in more than 10 cancer types. Because this analysis shows association rather than direction, both SSU72-to-partner and partner-to-SSU72 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RISC complex assembly grouped by SSU72-low versus SSU72-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SSU72→partner) and Y-score (partner→SSU72) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	RISC complex assembly →	+0.088	+0.549	<.001	<.001	3	11
BONE	Regulation of DNA stability →	+0.102	+0.423	.001	.002	3	10
BLOOD_Myeloma	Cellular response to methionine →	+0.093	+0.793	.006	<.001	3	10
BLOOD_Myeloma	Response to methionine →	+0.093	+0.793	.006	<.001	3	10
UPPER_AERODIGESTIVE_TRACT	Regulation of DNA-templated DNA replication →	+0.110	+0.693	<.001	<.001	3	10
KIDNEY	Positive regulation of cytoplasmic translational initiation →	+0.123	+0.663	.002	.001	1	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,165 associations by consensus.

RISC complex assembly by SSU72 expression — LARGE_INTESTINE

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