SSTR4

Across TCGA cell cohorts, SSTR4 mutation is significantly associated with the RNA expression of many other genes, with 355 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SSTR4-associated genes across cancer lineages are OR2AK2, SPINK9, and AGRP. Each is linked with SSTR4 in more than 1 cancer types. Because this analysis shows association rather than direction, both SSTR4-to-partner and partner-to-SSTR4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2AK2 grouped by SSTR4-low versus SSTR4-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SSTR4→partner) and Y-score (partner→SSTR4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	OR2AK2 →	+0.063	+5.285	<.001	.003	3	2
LARGE_INTESTINE	SPINK9 →	+0.197	+2.378	<.001	.006	3	2
LARGE_INTESTINE	AGRP →	+0.089	+2.257	.001	.009	3	2
LARGE_INTESTINE	TEX53 →	+0.059	+2.514	.003	.007	3	2
BLOOD_Leukemia	MYOD1 →	+0.022	+4.922	<.001	.009	3	1
BLOOD_Leukemia	LCE3D →	+0.065	+5.201	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 355 associations by consensus.

OR2AK2 by SSTR4 expression — STOMACH

Explore this box plot interactively →