SSTR2

Across TCGA patient cohorts, SSTR2 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SSTR2-associated genes across cancer lineages are PDK1_pS241, EGFR_pY1068, and INPP4B. Each is linked with SSTR2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SSTR2-to-partner and partner-to-SSTR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDK1_pS241 grouped by SSTR2-low versus SSTR2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SSTR2→partner) and Y-score (partner→SSTR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	PDK1_pS241 →	-0.218	-2.982	.021	.036	3	1
UCEC	EGFR_pY1068 →	-0.208	-1.807	.045	.027	3	1
UCEC	INPP4B →	-0.333	-3.321	.012	.009	3	1
UCEC	JNK_pT183_Y185 →	-0.183	-1.794	.008	.027	3	1
UCEC	Ku80 →	+0.272	+1.820	.005	.016	3	1
UCEC	MEK1 →	+0.333	+2.459	.027	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

PDK1_pS241 by SSTR2 expression — SKCM

Explore this box plot interactively →