SSTR2

Across TCGA pan-cancer cohorts, SSTR2 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of SSTR2’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where SSTR2 RNA is repressed in tumor relative to normal tissue. In most cancer types SSTR2 is over-expressed in tumor, although a few such as KICH and KIRP show the opposite, repressed pattern.

KICH, KIRP, and COAD are the cancer types where SSTR2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SSTR2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	All	IV	−2.255	<.001	11	view →
KIRP	Male	III,IV	−2.112	<.001	11	view →
COAD	Female	II,III,IV	−1.047	<.001	11	view →
HNSC	All	All	+0.342	.003	10	view →
BRCA	All	All	+1.211	<.001	6	view →
LUAD	All	All	+0.447	<.001	6	view →
KIRC	Male	II,III,IV	−0.654	<.001	5	view →
READ	All	All	−0.766	<.001	3	view →
PRAD	All	All	−0.589	<.001	2	view →
LUSC	All	All	+0.362	.033	1	view →
THCA	All	All	+0.195	.043	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

SSTR2–KICH

Open the KICH breakdown →