SSTR2

Across TCGA cell cohorts, SSTR2 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,246 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SSTR2-associated GO terms across cancer lineages are Cytoplasmic translation, Phospholipase C-activating G protein-coupled receptor signaling pathway, and RNA splicing, via transesterification reactions with bulged adenosine as nucleophile. Each is linked with SSTR2 in more than 8 cancer types. Because this analysis shows association rather than direction, both SSTR2-to-partner and partner-to-SSTR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cytoplasmic translation grouped by SSTR2-low versus SSTR2-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SSTR2→partner) and Y-score (partner→SSTR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Cytoplasmic translation →	+0.080	+1.694	<.001	.003	3	9
OVARY	Phospholipase C-activating G protein-coupled receptor signaling pathway →	-0.081	-0.509	<.001	.009	3	8
UPPER_AERODIGESTIVE_TRACT	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile →	+0.063	+0.106	.001	.004	3	8
UPPER_AERODIGESTIVE_TRACT	mRNA splicing, via spliceosome →	+0.063	+0.106	.001	.004	3	8
BREAST	Positive regulation of monoatomic ion transmembrane transport →	-0.111	-1.232	<.001	<.001	3	8
BREAST	Positive regulation of monoatomic ion transport →	-0.103	-0.831	<.001	.007	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,246 associations by consensus.

Cytoplasmic translation by SSTR2 expression — LUNG_SCLC

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