Across TCGA patient cohorts, SSPOP mutation is significantly associated with the RNA expression of many other genes, with 10,626 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SSPOP-associated genes across cancer lineages are CCDC43, CDCA2, and PRC1. Each is linked with SSPOP in more than 5 cancer types. Because this analysis shows association rather than direction, both SSPOP-to-partner and partner-to-SSPOP results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SSPOP→partner) and Y-score (partner→SSPOP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CCDC43 →	+0.410	+1.238	<.001	<.001	3	6
COAD	CDCA2 →	+0.603	+1.887	<.001	<.001	3	6
SKCM	PRC1 →	+0.509	+1.751	<.001	<.001	3	6
LUAD	EZH2 →	+0.576	+1.657	<.001	<.001	3	6
STAD	TXNL4A →	+0.395	+3.459	<.001	<.001	3	6
STAD	ACP1 →	+0.320	+1.959	.003	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,626 associations by consensus.

Exploration

SSPOP survival (RNA) · tumor vs normal (RNA) · all SSPOP data types