Across TCGA pan-cancer cohorts, SSPOP RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of SSPOP’s most consistent transcriptional readouts.
The strongest signal is observed in lung adenocarcinoma (LUAD), where SSPOP RNA is repressed in tumor relative to normal tissue. In most cancer types SSPOP is over-expressed in tumor, although a few such as LUAD and KICH show the opposite, repressed pattern.
LUAD, KICH, and THCA are the cancer types where SSPOP tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SSPOP RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.