SSMEM1

Across TCGA pan-cancer cohorts, SSMEM1 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated SSMEM1 data layer compared with 18 for mass-spec protein.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher SSMEM1 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated SSMEM1 expression acts as an unfavorable survival marker.

BRCA, OV, and SARC are the cancer types where SSMEM1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	DFS	Median	All	0.287	0.903	<.001	24	view →
OV	OS	Median	II,III,IV	0.511	0.844	.001	12	view →
SARC	DFS	Median	All	0.121	0.611	.041	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

SSMEM1–BRCA (DFS)

Open the BRCA breakdown →