SSMEM1

Across TCGA pan-cancer cohorts, SSMEM1 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of SSMEM1’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where SSMEM1 RNA is repressed in tumor relative to normal tissue. In most cancer types SSMEM1 is over-expressed in tumor, although a few such as LUAD and LUSC show the opposite, repressed pattern.

LUAD, LUSC, and BRCA are the cancer types where SSMEM1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SSMEM1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Male	II,III,IV	−0.389	<.001	9	view →
LUSC	Female	All	−0.377	<.001	6	view →
BRCA	All	II,III,IV	−0.066	<.001	6	view →
COAD	Female	IV	−0.105	.002	3	view →
UCEC	All	II,III,IV	−0.121	.047	2	view →
LIHC	All	All	+0.013	.007	2	view →
KIRP	Female	All	+0.058	.035	1	view →
BLCA	Female	III,IV	+0.048	.025	1	view →
KICH	All	All	−0.041	.022	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

SSMEM1–LUAD

Open the LUAD breakdown →