SSMEM1

Across TCGA patient cohorts, SSMEM1 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SSMEM1-associated genes across cancer lineages are FoxM1, Rab25, and TFRC. Each is linked with SSMEM1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SSMEM1-to-partner and partner-to-SSMEM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by SSMEM1-low versus SSMEM1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SSMEM1→partner) and Y-score (partner→SSMEM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.264	+3.179	.034	.010	3	1
UCEC	Rab25 →	-0.360	-2.459	.024	.020	3	1
UCEC	TFRC →	+0.699	+3.169	.006	.018	3	1
UCEC	TSC1 →	-0.203	-2.960	.014	.035	3	1
UCEC	Caspase-8 →	-0.321	-3.295	.008	.009	3	1
UCEC	Cyclin-B1 →	+0.651	+2.459	.016	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

FoxM1 by SSMEM1 expression — UCEC

Explore this box plot interactively →