SSMEM1

Across TCGA cell cohorts, SSMEM1 RNA expression is significantly associated with the go_rna of many other GO terms, with 882 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible SSMEM1-associated GO terms across cancer lineages are Regulation of protein K48-linked ubiquitination, Succinate transport, and Regulation of determination of dorsal identity. Each is linked with SSMEM1 in more than 4 cancer types. Because this analysis shows association rather than direction, both SSMEM1-to-partner and partner-to-SSMEM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of protein K48-linked ubiquitination grouped by SSMEM1-low versus SSMEM1-high in LUNG_NSCLC_LUAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SSMEM1→partner) and Y-score (partner→SSMEM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	Regulation of protein K48-linked ubiquitination →	+0.118	+0.039	<.001	<.001	3	5
SOFT_TISSUE	Succinate transport →	-0.145	-0.070	.005	.003	3	4
SOFT_TISSUE	Regulation of determination of dorsal identity →	+0.126	+0.050	.001	.005	3	4
LARGE_INTESTINE	Mitotic nuclear membrane organization →	+0.047	+0.014	.009	.001	3	4
LARGE_INTESTINE	Mitotic nuclear membrane reassembly →	+0.047	+0.014	.009	.001	3	4
SOFT_TISSUE	Succinate transmembrane transport →	-0.145	-0.070	.005	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 882 associations by consensus.

Regulation of protein K48-linked ubiquitination by SSMEM1 expression — LUNG_NSCLC_LUAD

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