SSH3

Across TCGA pan-cancer cohorts, SSH3 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated SSH3 data layer compared with 25 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in glioblastoma multiforme (GBM), where higher SSH3 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated SSH3 expression acts as an unfavorable survival marker, although some lineages such as HNSC and PDAC show a favorable association.

GBM, HNSC, and PDAC are the cancer types where SSH3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
GBM	OS	Tertile	All	0.379	0.689	<.001	31	view →
HNSC	DFS	Quartile	All	0.924	0.558	.001	24	view →
PDAC	OS	Median	IV	0.937	0.395	.026	3	view →
CCRCC	OS	Median	III,IV	1.000	0.842	.041	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

SSH3–GBM (OS)

Open the GBM breakdown →