SSH3

Across TCGA pan-cancer cohorts, SSH3 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of SSH3’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where SSH3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SSH3 is over-expressed in tumor, although a few such as UCEC and PRAD show the opposite, repressed pattern.

KIRP, LUAD, and THCA are the cancer types where SSH3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SSH3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	All	II,III,IV	+1.160	<.001	11	view →
LUAD	Female	II,III,IV	+0.553	<.001	8	view →
THCA	Male	All	+0.453	<.001	8	view →
LIHC	Female	II,III,IV	+1.158	<.001	7	view →
BRCA	All	II,III,IV	+0.409	.001	6	view →
CHOL	Male	All	+2.495	<.001	5	view →
HNSC	All	All	+0.470	.002	5	view →
STAD	Male	II,III,IV	+0.794	.015	3	view →
COAD	Female	All	+0.334	.008	3	view →
LUSC	All	All	+0.303	.017	3	view →
PAAD	All	All	+1.319	.020	2	view →
UCEC	All	II,III,IV	−0.982	.041	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

SSH3–KIRP

Open the KIRP breakdown →