SSH3

Across TCGA patient cohorts, SSH3 mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SSH3-associated genes across cancer lineages are GSK-3a-b_pS21_S9, MSH2, and TAZ. Each is linked with SSH3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SSH3-to-partner and partner-to-SSH3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GSK-3a-b_pS21_S9 grouped by SSH3-low versus SSH3-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SSH3→partner) and Y-score (partner→SSH3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	GSK-3a-b_pS21_S9 →	+0.357	+3.000	.015	.034	3	1
BLCA	MSH2 →	+0.296	+2.584	.003	.011	3	1
BLCA	TAZ →	-0.195	-2.584	.005	.011	3	1
BLCA	Chk2 →	+0.227	+2.999	.022	.035	3	1
BLCA	Collagen-VI →	-0.303	-2.999	.032	.035	3	1
UCEC	eEF2 →	+0.296	+2.999	.040	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

GSK-3a-b_pS21_S9 by SSH3 expression — BLCA

Explore this box plot interactively →