SSH3

Across TCGA cell cohorts, SSH3 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,772 significant associations in total. BONE shows the largest number of these associations.

The most reproducible SSH3-associated GO terms across cancer lineages are Toll-like receptor 7 signaling pathway, T cell mediated immunity, and Cilium movement involved in cell motility. Each is linked with SSH3 in more than 14 cancer types. Because this analysis shows association rather than direction, both SSH3-to-partner and partner-to-SSH3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Toll-like receptor 7 signaling pathway grouped by SSH3-low versus SSH3-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SSH3→partner) and Y-score (partner→SSH3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Toll-like receptor 7 signaling pathway →	+1.152	+1.637	<.001	<.001	3	15
URINARY_TRACT	T cell mediated immunity →	+0.198	+1.608	<.001	.003	3	12
UPPER_AERODIGESTIVE_TRACT	Cilium movement involved in cell motility →	-0.114	-1.317	.001	.001	3	12
BONE	Plasma membrane organization →	+0.186	+2.143	<.001	<.001	3	12
URINARY_TRACT	Small GTPase-mediated signal transduction →	+0.078	+2.018	<.001	<.001	3	12
BONE	Negative regulation of actin filament polymerization →	+0.132	+2.301	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,772 associations by consensus.

Toll-like receptor 7 signaling pathway by SSH3 expression — LUNG_SCLC

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