SSH2

Across TCGA patient cohorts, SSH2 mutation is significantly associated with the RNA expression of many other genes, with 4,598 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SSH2-associated genes across cancer lineages are YIPF5, MAK16, and MRPS27. Each is linked with SSH2 in more than 3 cancer types. Because this analysis shows association rather than direction, both SSH2-to-partner and partner-to-SSH2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, YIPF5 grouped by SSH2-low versus SSH2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SSH2→partner) and Y-score (partner→SSH2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	YIPF5 →	+0.431	+3.499	.009	.002	3	4
STAD	MAK16 →	+0.523	+2.601	.001	.006	3	4
COAD	MRPS27 →	+0.452	+3.210	.002	.009	3	4
UCEC	EXOSC9 →	+0.307	+2.134	.003	<.001	3	4
UCEC	EIF2S1 →	+0.381	+1.380	.001	.003	3	4
UCEC	PGAM1 →	+0.521	+1.375	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,598 associations by consensus.

YIPF5 by SSH2 expression — COAD

Explore this box plot interactively →