SSH1

Across TCGA cell cohorts, SSH1 mutation is significantly associated with the RNA expression of many other genes, with 266 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SSH1-associated genes across cancer lineages are MRGPRG, LYPD4, and GSG1L2. Each is linked with SSH1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SSH1-to-partner and partner-to-SSH1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MRGPRG grouped by SSH1-low versus SSH1-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SSH1→partner) and Y-score (partner→SSH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	MRGPRG →	+0.333	+4.930	<.001	.008	3	2
SOFT_TISSUE	LYPD4 →	+0.016	+5.977	<.001	.001	3	2
KIDNEY	GSG1L2 →	+0.033	+5.000	<.001	.005	3	2
BLOOD_Leukemia	PROP1 →	+0.021	+3.704	<.001	.001	3	2
URINARY_TRACT	CHIA →	+1.476	+5.087	<.001	.004	3	1
BLOOD_Lymphoma	SLC38A8 →	+0.059	+4.191	.004	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 266 associations by consensus.

MRGPRG by SSH1 expression — SOFT_TISSUE

Explore this box plot interactively →