SSH1

Across TCGA pan-cancer cohorts, SSH1 RNA is linked to patient survival in 28 of 34 cancer types, making it the most broadly survival-associated SSH1 data layer compared with 3 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher SSH1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SSH1 expression acts as an unfavorable survival marker, although some lineages such as UCS and SCLC show a favorable association.

LUSC, LIHC, and UCS are the cancer types where SSH1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	DFS	Tertile	III,IV	0.454	1.000	.003	55	view →
LIHC	DFS	Tertile	All	0.418	0.630	<.001	52	view →
UCS	DFS	Quartile	II,III,IV	0.620	0.229	<.001	48	view →
LGG	OS	Median	All	0.751	0.876	<.001	41	view →
OV	OS	Tertile	III,IV	0.764	0.865	.009	32	view →
SCLC	DFS	Quartile	II,III,IV	0.954	0.545	.005	28	view →
ACC	DFS	Median	All	0.539	0.778	.002	23	view →
BLCA	OS	Quartile	II,III,IV	0.682	0.813	.006	19	view →
STAD	DFS	Median	IV	0.161	0.562	.023	18	view →
HNSC	DFS	Quartile	IV	0.435	0.281	.006	15	view →
KIRC	DFS	Tertile	All	0.792	0.558	.007	14	view →
BRCA	DFS	Tertile	III,IV	0.872	0.724	.006	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 28 lineages.

SSH1–LUSC (DFS)

Open the LUSC breakdown →