SSC5D

Across TCGA patient cohorts, SSC5D mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SSC5D-associated genes across cancer lineages are Shc_pY317, TFRC, and EGFR_pY1068. Each is linked with SSC5D in more than 1 cancer types. Because this analysis shows association rather than direction, both SSC5D-to-partner and partner-to-SSC5D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Shc_pY317 grouped by SSC5D-low versus SSC5D-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SSC5D→partner) and Y-score (partner→SSC5D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Shc_pY317 →	-0.157	-1.691	.014	.043	3	2
COAD	TFRC →	+0.405	+2.841	.046	.033	3	2
UCEC	EGFR_pY1068 →	-0.191	-1.362	.031	.037	3	2
UCEC	ATM →	-0.668	-2.874	<.001	<.001	3	2
COAD	GAPDH →	+0.513	+2.230	.007	.006	2	2
COAD	Lck →	+0.243	+2.932	.037	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

Shc_pY317 by SSC5D expression — COAD

Explore this box plot interactively →