SSC5D

Across TCGA pan-cancer cohorts, SSC5D RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of SSC5D’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where SSC5D RNA is repressed in tumor relative to normal tissue. In most cancer types SSC5D is over-expressed in tumor, although a few such as BLCA and UCEC show the opposite, repressed pattern.

BLCA, UCEC, and KICH are the cancer types where SSC5D tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SSC5D RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	Male	IV	−2.807	<.001	8	view →
UCEC	All	III,IV	−3.292	<.001	6	view →
KICH	Female	All	−1.709	<.001	6	view →
COAD	Female	II,III,IV	−1.115	<.001	6	view →
LIHC	Male	All	−0.667	<.001	4	view →
HNSC	All	II,III,IV	+0.645	.017	4	view →
LUSC	All	All	−0.619	.003	4	view →
STAD	Female	All	−2.022	.008	3	view →
CHOL	All	All	+0.987	.001	3	view →
READ	Female	All	−2.583	.001	2	view →
PRAD	All	All	−0.503	.010	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

SSC5D–BLCA

Open the BLCA breakdown →