SSC5D

Across TCGA cell cohorts, SSC5D mutation is significantly associated with the RNA expression of many other genes, with 69 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SSC5D-associated genes across cancer lineages are GPR12, CYP4F8, and S100G. Each is linked with SSC5D in more than 2 cancer types. Because this analysis shows association rather than direction, both SSC5D-to-partner and partner-to-SSC5D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GPR12 grouped by SSC5D-low versus SSC5D-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SSC5D→partner) and Y-score (partner→SSC5D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	GPR12 →	+0.876	+3.736	<.001	.008	3	2
SKIN	CYP4F8 →	+0.013	+3.217	.003	.006	3	2
BREAST	S100G →	+0.401	+4.378	<.001	<.001	3	2
CNS	CR2 →	+0.470	+3.487	<.001	.005	2	3
STOMACH	DYNAP →	+0.076	+2.959	<.001	.004	3	2
SOFT_TISSUE	MYF6 →	+0.961	+3.865	.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 69 associations by consensus.

GPR12 by SSC5D expression — SOFT_TISSUE

Explore this box plot interactively →