SSC4D

Across TCGA patient cohorts, SSC4D mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SSC4D-associated genes across cancer lineages are Shc_pY317, JNK2, and Myosin-IIa_pS1943. Each is linked with SSC4D in more than 1 cancer types. Because this analysis shows association rather than direction, both SSC4D-to-partner and partner-to-SSC4D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Shc_pY317 grouped by SSC4D-low versus SSC4D-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SSC4D→partner) and Y-score (partner→SSC4D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Shc_pY317 →	-0.204	-2.700	.002	.006	3	2
UCEC	JNK2 →	+0.322	+2.000	<.001	.032	3	1
UCEC	Myosin-IIa_pS1943 →	+0.190	+2.013	.040	.018	3	1
UCEC	p62 Lck ligand →	+0.556	+3.331	<.001	.005	3	1
UCEC	PI3K-p110-a →	-0.181	-2.700	.022	.006	3	1
UCEC	PRAS40_pT246 →	+0.182	+2.013	.019	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

Shc_pY317 by SSC4D expression — UCEC

Explore this box plot interactively →