SSC4D

Across TCGA pan-cancer cohorts, SSC4D RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated SSC4D data layer compared with 6 for mutation status.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher SSC4D RNA is associated with worse overall survival. In most high-consensus cancer types, elevated SSC4D expression acts as an unfavorable survival marker, although some lineages such as UVM and THCA show a favorable association.

KIRP, UCEC, and BLCA are the cancer types where SSC4D RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Median	II,III,IV	0.231	0.827	.001	121	view →
UCEC	OS	Tertile	All	0.568	0.910	<.001	88	view →
BLCA	DFS	Median	All	0.276	0.400	.005	59	view →
KIRC	OS	Median	All	0.567	0.692	.002	44	view →
UVM	DFS	Quartile	II,III,IV	0.789	0.347	.001	43	view →
LGG	OS	Tertile	All	0.669	0.861	<.001	32	view →
COAD	OS	Quartile	II,III,IV	0.407	0.762	.003	32	view →
THCA	DFS	Tertile	III,IV	0.945	0.414	.006	23	view →
SCLC	DFS	Quartile	II,III,IV	0.461	0.899	.003	18	view →
UCS	DFS	Tertile	IV	0.321	0.829	.024	12	view →
GBM	OS	Quartile	All	0.213	0.402	.001	11	view →
MESO	OS	Quartile	IV	0.935	0.230	.008	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

SSC4D–KIRP (OS)

Open the KIRP breakdown →