SSB

Across TCGA pan-cancer cohorts, SSB mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SSB data layer compared with 21 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SSB mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated SSB expression acts as an unfavorable survival marker, although some lineages such as GBM and LSCC show a favorable association.

HNSC, GBM, and LSCC are the cancer types where SSB mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Quartile	III,IV	0.834	1.000	.010	36	view →
GBM	OS	Median	All	0.653	0.437	.011	10	view →
LSCC	OS	Tertile	II,III,IV	0.941	0.651	.030	5	view →
PDAC	OS	Median	III,IV	0.919	0.608	.041	1	view →
LUAD	DFS	Quartile	All	0.985	0.865	.044	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

SSB–HNSC (DFS)

Open the HNSC breakdown →