SS18

Across TCGA cell cohorts, SS18 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SS18-associated genes across cancer lineages are GSG1L2, TMEM207, and OR4E1. Each is linked with SS18 in more than 1 cancer types. Because this analysis shows association rather than direction, both SS18-to-partner and partner-to-SS18 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GSG1L2 grouped by SS18-low versus SS18-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SS18→partner) and Y-score (partner→SS18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GSG1L2 →	+0.013	+4.022	<.001	.006	3	1
BREAST	TMEM207 →	+0.162	+4.672	<.001	.002	3	1
BREAST	OR4E1 →	+0.112	+4.781	<.001	.003	3	1
BREAST	NMRK2 →	+0.039	+4.199	<.001	.007	3	1
BLOOD_Lymphoma	C1orf87 →	+0.021	+4.867	.008	.009	3	1
BLOOD_Lymphoma	ART5 →	+0.122	+4.867	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

GSG1L2 by SS18 expression — LARGE_INTESTINE

Explore this box plot interactively →