Across TCGA patient cohorts, SRY mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible SRY-associated genes across cancer lineages are LINC01014, DNMT3L-AS1, and MTCO1P48. Each is linked with SRY in more than 1 cancer types. Because this analysis shows association rather than direction, both SRY-to-partner and partner-to-SRY results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SRY→partner) and Y-score (partner→SRY) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	LINC01014 →	+0.315	+4.324	.002	.007	3	1
COAD	DNMT3L-AS1 →	+0.171	+5.271	<.001	.001	3	1
COAD	MTCO1P48 →	+0.044	+4.693	.007	.007	3	1
COAD	TUBAP8 →	+0.073	+4.446	.001	.006	3	1
COAD	RNU2-60P →	+0.297	+4.602	.007	.008	3	1
SKCM	HIGD1AP8 →	+0.168	+4.695	.003	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

Exploration

SRY survival (RNA) · tumor vs normal (RNA) · all SRY data types