SRXN1

Across TCGA patient cohorts, SRXN1 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible SRXN1-associated genes across cancer lineages are RNU6-408P, RNU6-768P, and FAM197Y1. Each is linked with SRXN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SRXN1-to-partner and partner-to-SRXN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-408P grouped by SRXN1-low versus SRXN1-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SRXN1→partner) and Y-score (partner→SRXN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RNU6-408P →	+0.727	+8.471	<.001	.005	3	1
SKCM	RNU6-768P →	+0.282	+7.816	<.001	.008	3	1
SKCM	FAM197Y1 →	+0.049	+7.816	<.001	.008	3	1
SKCM	PRAMEF32P →	+0.034	+7.816	<.001	.008	3	1
BRCA	MTND1P35 →	+0.059	+7.731	<.001	.009	3	1
SKCM	LDHBP3 →	+0.044	+7.816	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

RNU6-408P by SRXN1 expression — BRCA

Explore this box plot interactively →