SRSF4

Across TCGA patient cohorts, SRSF4 RNA expression is significantly associated with the protein abundance of many other proteins, with 11,083 significant associations in total. GBM shows the largest number of these associations.

The most reproducible SRSF4-associated proteins across cancer lineages are PPP1R8, RPA1, and RPS6KA1. Each is linked with SRSF4 in more than 4 cancer types. Because this analysis shows association rather than direction, both SRSF4-to-partner and partner-to-SRSF4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SRSF4 versus PPP1R8 in GBM, with a Pearson correlation of 0.53.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SRSF4→partner) and Y-score (partner→SRSF4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PPP1R8 →	+0.205	+0.290	<.001	<.001	3	5
GBM	RPA1 →	+0.394	+0.295	<.001	<.001	3	4
LUAD	RPS6KA1 →	+0.453	+0.508	<.001	<.001	3	4
GBM	DNAJC8 →	+0.350	+0.352	<.001	<.001	3	4
BRCA	LRRC47 →	+0.181	+0.407	<.001	<.001	3	4
PDAC	PHACTR4_S464 →	+1.093	+0.249	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,083 associations by consensus.

SRSF4 vs PPP1R8 — GBM

Explore this scatter interactively →