SRSF4

Across TCGA patient cohorts, SRSF4 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SRSF4-associated genes across cancer lineages are ATM, 14-3-3_beta, and eIF4E. Each is linked with SRSF4 in more than 1 cancer types. Because this analysis shows association rather than direction, both SRSF4-to-partner and partner-to-SRSF4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by SRSF4-low versus SRSF4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SRSF4→partner) and Y-score (partner→SRSF4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.567	-2.000	.001	.010	3	2
UCEC	14-3-3_beta →	-0.105	-3.432	.007	.005	3	1
UCEC	eIF4E →	+0.167	+3.013	.043	.018	3	1
UCEC	ERCC1 →	-0.142	-2.459	.036	.019	3	1
UCEC	ACVRL1 →	-0.155	-2.000	.003	.010	3	1
UCEC	Ku80 →	+0.206	+1.598	.026	.022	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

ATM by SRSF4 expression — UCEC

Explore this box plot interactively →